Slightly. To get an optimum traction and track-holding balance you start by considering the relative axle loads. Driving axles for instance provide best traction when equally loaded. The axle loads and their spacings mathematically determine where the centre of gravity will need to be in the completed loco. This may influence the driveline layout in order to provide the optimum placing of voids in which to locate ballast to achieve the desired centre of gravity. In a parallel analytical thread, the axle loads and their spacings, via the spreadsheet, determines where the spring anchors need to be.
The technique has been around long enough now for various rules of thumb to have emerged regarding relationships between driving and carrying wheel axle loads, acceptable tweaks to anchor locations, wire diameters etc.