The book on build an 0-6-0 (that is already suggested above) will answer many of them. It follows one persons build. There are some things that I would disagree on, like the keeper plate method for the wheels.
There is a second book on split frame chassis construction. Also available from the 2mm SA Shop 1, or if you are not already a member (why not ) it is available from any exhibition that the 2mm SA association stand attends. This is possibly better than the above book because it gives the principles, reasons and ideas for this method of construction.
Other replies have answered most of these questions. N Brass Locos also offer 0-6-0 chassis (think frames and connecting rods) which I believe are based on a SECR C class, but there's every chance I am wrong.
The supply is not isolated from the chassis. You have to make sure that the frames are isolated from each other. This is explained by the principles of split frame chassis construction.
Gearboxes are usually built into the frame to make the most of the small space available between the frames (usually 6-7mm depending on the material used for the frames). Thus when planning the frames you will also plan additional holes to site the shafts for the gears to sit on. (These are also split and joined by an insulating sleeve, like the locomotive wheels)