Interesting topic that I can relate to directly!
I am (was!) right handed until just over a year ago when I lost the use of my right arm and hand. It started with a mild shoulder pain and developed over 3-4 weeks (see here for full details if interested http://rarediseases.org/rare-diseases/parsonage-turner-syndrome/)into complete inability to lift or do anything with my right arm and no feeling in most of my hand.
So I was immediately faced with having to become left handed to do anything - eat, wash, shave (and other personal admin. tasks!!), drink, dress etc. obviously came first, followed pretty soon after that by work - luckily I am a desk-jockey but just try a while to go to left handed mouse control - takes a bit of getting used to
Anyway, hobbies had to take a back seat for quite a while - even trying to remove a loco body and fit a plug in decoder was pretty much impossible with only one hand, and that one being the wrong one I have a small shunting layout in build, but that had been sidelined a few months before due to household jobs & DIY demands.
However, after 6-7 months or so the nerves started to recover/repair and I developed some arm movement. This meant I could 'plonk' my duff hand in places to hold things down and this allowed me to gradually do simple things in the hobby arena. However things like soldering that definitely needed 2(3?) hands were still way out of sight, plus I had been warned off hot things following a bad burn suffered when stir frying (no feeling in my finger ).
The development of my 'left handedness' progressed quite quickly and soon I was using a cordless drill and had developed sufficient strength to use screwdrivers left handed. Use of a hammer was tricky though!
After 9 months I pretty much considered myself left handed but there were still things that defied my ability - using scissors left handed (weird) for example.
Attendance at the excellent Wessex Rehab at Salisbury Hospital stimulated me not only physically but also mentally to try tasks.
Now I have more strength in my right arm, some in the wrist and a little grip, I am able to hold things in my right hand and so some modelling tasks are back on the agenda - I have embarked on a Scalescenes Boxfile layout as a form of rehab.
I think I will be left handed for a while yet, then the challenge will be to start using my right again - hopefully I will then be ambidextrous
So it is remarkable how we can adapt and find new ways to do things when challenged - motivation has lot to do with it and I am lucky that this hobby has helped me.
I can now well appreciate the challenges faced by the left handed as well as those with disabilities, injuries, arthritis etc..
I can't think of anything I have felt the need to alter or move round at home since becoming left handed, the problems have mostly come from being one handed!
I am able to drive now but thinking about it - just try getting the car key in the ignition with your left hand when the steering lock is on the right!!!