BR tried Gresley's U1 Garratt on Lickey. Evidently, local crews despised the smoke, so normally ran cab-end-first up the hill. Running thusly led to water not consistently covering the firebox, which led to crews filling more water, which led to priming and a shortened boiler life. Eventually replaced with a 9F wearing Bertha's electric light.
I'd imagine, unless they pulled a crew off of the Toton coal run, that any LMS-built Garratt would have had the same issue.