Early Risers.

[Ozexpatriate]

38 minutes ago, jamie92208 said:

A hangar is an open fronted shed probably the derivation of the word used for somewhere to store aeroplanes. 

Google suggests for the etymology:

 

FRENCH - late 17th century (in the sense ‘shelter’): from French; probably from Germanic bases meaning ‘hamlet’ and ‘enclosure’.

 

Certainly the aeroplane interpretation is from French as are many aeronautical terms - like: fuselage, empennage, aileron, etc.

[BSW01]

Good evening everyone 

 

Well, the weather has been very kind to me today, so I’ve had a very productive day in the garden. The front garden is now looking a bit tidier, but also a bit emptier too, although I still have a few more plants I can use to fill the spaces with. The weather forecast for tomorrow is good, doesn’t look good, so if it’s raining then I’ll spend the day in the workshop instead. If it’s not raining, then a bit more gardening will be done. 

[BSW01]

Goodnight all 

[BR60103]

We've had 2 sheds, both of the tin variety. One came with our last house and was used mainly for garden storage (and bicycles). The one at the trailer was all gardeny stuff.

Went to GBTS today as visitor. Saw many old friends. Stayed for 1 1/2 hours. Won't say more for fear of awl.

Traffic on the way home was horrible but we left the expressway and went through town.

 

[iL Dottore]

20 hours ago, jjb1970 said:

Shi En (who travelled with me) almost makes Il Dottore look low rent when it comes to food standards, 

I’m glad that you added that qualifier JJB. Although it is true that my knowledge of SE Asian food is not as extensive as I’d like it to be.

 

I wonder what Shi En would makes of PB’s culinary world (standards, efforts, menus etc.).

20 hours ago, polybear said:

Welcome to The List.....

20 hours ago, Dave Hunt said:

Does my double garage and 35ft x 20ft shed get me on the list then Bear?

 

Dave

 

Oh, and the fact that I’ve got cake in stock?

20 hours ago, Hroth said:

I'm on so many "Lists" that I've forgotten which list that is...

🙃

20 hours ago, Winslow Boy said:

Don't worry I'll remind you every so often by getting Bear to mention the fact that I'm on it as well.

19 hours ago, polybear said:

Anything bigger than a Bear's Shed counts.

I wouldn’t worry too much about being “on the list”. The list being, I am reliably assured, scrawled in green crayon on lined paper.

 

To be honest, I quite like “being on the list”, after all being on The List means that you have ANNOYED THE BEAR, which is a noble and fine endeavour.

 

Unfortunately, moving will mean that I will have to trade my underground, “nuclear shelter” type shed for a “bastelraum” in the flat and TWO parking spaces (with associated storage) in the secure underground, garage.

 

Still in return in addition to the usual rooms I’ll get a small loggia with a Japanese garden in it and a decent kitchen that can be, with some equipment changes, as professional a kitchen as you can get away with in a private dwelling.

[iL Dottore]

19 hours ago, TheQ said:

Got back to find the postie has been...  I've been invited to join a joint NHS / company / university trial for Oral SemaGlutide, it's a 5 year trial, .. This is an oral version of the drug wealthy people/ actors have been taking to lose weight. It's real purpose it to control diabetes with a side effect of reducing heart attacks and strokes..Looking it up it's an expensive drug, it appears to be a deltic*** to two deltics a month depending on strengths. I'm inclined to join the trial, I hope I get the real thing not a placebo, I'd soon know, it has a side effect of... Gas gas gas....

Not necessarily, if a certain adverse event is seen in a large percentage of a patient population it doesn’t mean that you will experience that adverse event, just that you have a high probability of experiencing that AE.

 

In one oncology study I worked on significant hypotension was a common AE seen immediately after treatment and although most patients experienced hypotension, a number did not.

19 hours ago, Tony_S said:

Aditi was offered that too. She declined as her diabetes is well controlled with two medications and she didn’t want to replace it with a placebo. The information provided was not clear about whether or not existing medication was altered. If there had been a bit more information she might have made more enquiries. 
 

Depends upon the study design and the disease being treated. In life threatening disease, studies are designed so that patients get either <standard of care + new drug> or <standard of care + placebo>.

Unfortunately, in some countries and/or some diseases <standard of care> means no treatment at all beyond managed decline.

 

It is a sad commentary on the state of many health services across the world that sometimes the only way to access state of the art care is to sign up to a clinical trial.

18 hours ago, polybear said:

Now Bear might be being overly cynical here (no doubt iD will correct me if I’m wrong) but don’t the Docs get paid (by the Drug Manufacturer?) for every patient signed up?

Nope, the physicians don’t get paid, the hospitals/clinics/institutions where the study is placed get paid per patient - but this is to pay for the blood work/scans/assessments/specialised pharmacy, nursing and study staff needed by a clinical trial (some institutions are notorious for charging eye gouging mark-ups on the otherwise routine tests required by a clinical trial).

 

The average per-patient cost in an oncology trial (which excludes things like data management or production of study drug) is about £50,000 (and can go much higher).

18 hours ago, Tony_S said:

No idea. I do understand why medics like placebo trials but possibly withholding treatment from someone who needed it and perfectly good treatments existed seemed wrong especially as it required her to taken  the clinic  day for a month or so. Poor Mum, who had always allowed extra samples  for research or allowed doctors to try and see if something worked, felt guilty fro not helping. I looked up the research and told her she wasn’t exactly holding up scientific progress. There were hundreds of similar projects in the English speaking world, some of whom had already published.
There was none of that sort of thing when she moved to Worcestershire. Her treatment for all her conditions there was really good. 

No clinical trial withholds essential treatment from a patient (see my earlier comment). To do so would be unethical, immoral and counterproductive (not to mention that the regulatory agencies would descend like a ton of bricks on any clever clogs trying to do so). This might have happened in the 50s and 60s, but not today.

 

EVERY clinical study - both observational and interventional - has to be approved by the local IRB (institutional review board)/ethics committee before being allowed to proceed. Having had to - in person - justify to a German IRB why it was necessary to perform more CT scans than local standard of care, I can tell you they are NO pushover (definitely one of the toughest meetings I’ve ever been in. Even tougher than getting an extra $20 million out of senior management). 
 

As for the second highlighted point - just because to a layman they seem similar, doesn’t mean they are. Different patient populations, different regimens, different drug mode-of-actions - all relevant differences (and given the cost of a clinical trial no-one does one “just for the hell of it”). As for results being published: that doesn’t mean everything is “done and dusted”. Every single drug (or surgical intervention or other patient intervention) gets continuously studied and monitored during its effective lifespan - frequently leading to new therapeutic interventions and ALWAYS to new safety data.

 

Edited April 28 by iL Dottore
Missing word

[jamie92208]

Beth is on Ozempic as well as insulin. The pharmacist has had supply problems due to the yuppy use as a weight loss drug. 

 

Here the sun is shining, for the moment.  Neighbours cat to be fed, the market to be visited and the bird feeders to be filled. Then get some meat from the freezer for tonight's tea.  Then after lunch off to Angouleme to visit. 

 

Ttfn. 

 

Jamie

[Barry O]

Ey up!

 

Quite a while ago I took part in some clinical trials using z variety of drugs. Eventually I started on a daily injection of semiglutide.. weight loss was noticeable.

 

I had been on a weekly ozempic jab but its not available for the next year or so.. so they switched me to Rybelsus.. aka semiglutide tablets taken daily. These are a faff and don't seem to be as effective as the jab was.

 

The trials were looking at diabetes effects on the heart. Cardiff specialist hate metformin  with a vengeance (as well as starting which they are pretty critical about)

 

Back to today. Its wet.. pah!

Her indoorsbis off out playing crumhorns and recorders today. A bit of wire strangling may be achieved. Wooppppiiiiddddooo!

 

Stay safe!

 

@grandadbob get a plan of where you want to visit at Beamish then look at how you can get there by bus tram etc. That way it reduces the walking to get anywhere bit..

 

Baz

[TheQ]

Mooring Awl,

6 hours sleep with a couple of wake up and turn overs, then 2 hours semi dozing.

 

Forepaws and right ankle reminding me of the weather, has been extremely soggy overnight, light fine drizzle at the moment, more soggyness due shortly according to the radar.

 

Ben the impatient Collie was very happy on patrol, but kept stopping looking back at me and saying hurry up..

 

I'll be going to the sailing club anyway, but with winds gusting up to 15 to 38mph there's not much chance of me sailing, it doesn't then seem worth uncovering the boat to get it all wet.

I'll probably come home via the orange shed for what will be the last load of sand , wheel tracks and hollows for the filling in of.

 

If they were to take me off metformin and only be on the placebo I'd definitely know quickly as my blood tests would show my sugar levels climbing. I would only proceed if metformin would be continued even if on a reduced dose...

 

 

Time to finish my muggacoffee and head to the SC.

[Hroth]

Dry this morning, but grey and unseasonably cool.  Its almost MAY, where's the warm?  Although next thing it'll be "Phew! What a scorcher!", with hosepipe bans and we'll be longing for some cool weather.  Unless, that is, it turns into "The Year Without A Summer"...

 

 

[polybear]

10 hours ago, jamie92208 said:

As to sheds, the main one is 10m by 40m with a 70 sq metre hangar attached which is the woodshed, there is also a 30 sq metre hangar on the opposite side which is now Cluckingham Palace. new inhabitants will arrive in June before Emily visits in August.  Oh and there is a 5 sq M pool shed as well to house the pump and chemicals., pool toys erc.  Is that enough to get me on the list.?

 

 

Oh yes - Pole Position with @The Q I'd say.

 

2 hours ago, iL Dottore said:

I wonder what Shi En would makes of PB’s culinary world (standards, efforts, menus etc.).

 

Would Bear be bovvered?

 

 

[grandadbob]

Good morning all,

Dull and very damp, seems to have been raining for hours.  More rain to come yet and it may be heavy and thundery. Chance of some sunny spells later this afternoon and it will be breezy.  7°C rising to 13°C.

@Barry O  Beamish was big enough in 2019 and we spent a day and a half there and walked IIRC about 12 miles.  Don't intend doing that again, don't think various joints would cope so buses and trams will be used.   A plan will be made and one or two things won't be visited, I certainly won't be going in the coal mine again, even that short distance in there walking doubled up was more than enough for my poor old back.  

Rugby watched yesterday and it was a great match.  Must have been a fantastic atmosphere at Twickenham with 60000 rugby fans enjoying the spectacle.  A couple of controversial refereeing decisions to the benefit of both sides but I think Quins possibly did better out of it and managed to secure a great win which they badly needed.  More rugby to watch this afternoon.  No surprise there then.

As it's Sunday a cooked breakfast has been offered so I will shortly be surrounding some eggs, bacon sausage etc.

Have a good one,

Bob.

[New Haven Neil]

Morning, from a cool but sunny rock, 10c feels like alot less. Absolutely knackered after that walk yesterday, the rough ground has played havoc with everything.

[Dave Hunt]

10 hours ago, Ozexpatriate said:

Certainly the aeroplane interpretation is from French as are many aeronautical terms - like: fuselage, empennage, aileron, etc.

One of the most widely used aeronautical terms I remember from my career was, “Ohhhh sh!!!!tt.” Is that from the French?

 

Dave

[jamie92208]

8 minutes ago, Dave Hunt said:

One of the most widely used aeronautical terms I remember from my career was, “Ohhhh sh!!!!tt.” Is that from the French?

 

Dave

No they would use Merde which can also mean mud and soil. 

 

Jamie

[Coombe Barton]

About other languages:

 

In 1983 I was skiing in Livigno and this tree reached out and grabbed me. My wrist hurt.

 

I got shunted off to the local clinic in the village which had x-ray facilities. The doc had about as much English as I had Italian, i.e. very little. Summary of conversation (Doc in very heavily accented Italian:

 

Doc: “Is beautiful break.”

 

Me: “Oh sh1t!”

 

Doc: “Sh1t?”

 

Me: “Si, sh1t.”

 

Doc: “Che?”

 

Me: “En Français?”

 

Doc: “Si.”

 

Me: “Merde.”

 

And then he started practicing. All I heard was “Sh1t …sh1t … sh1t …”

[Winslow Boy]

31 minutes ago, Dave Hunt said:

One of the most widely used aeronautical terms I remember from my career was, “Ohhhh sh!!!!tt.” Is that from the French?

 

Dave

Getting a bit technical there Squadron Leader.

[Hroth]

53 minutes ago, Dave Hunt said:

One of the most widely used aeronautical terms I remember from my career was, “Ohhhh sh!!!!tt.” Is that from the French?

 

Dave

 

Every landing you walk away from is a successful "Ohhhh sh!!!!tt"....

 

[PhilJ W]

Morning all from Estuary-Land. After yesterday's perambulations at the exhibition the arthritis was playing up a bit so before going to bed I took some co-codamol. The result was six hours solid sleep until I had a call-out from bladder control after which I went back to sleep for another hour and a half. Only the odd twinge from the arthritis this morning but a couple of Nurofen sorted that.

[polybear]

Bear here.....

 

Up at Disgustinglylateo'clock this morning (0725) - bearing in mind I climbed The Little Wooden Hill at half nine last night that's quite a snooze, despite being disturbed by that little b1tch the Wee Wee Fairy twice 😒.

Now fully wallowed and Beary Pit made, so Bear's on a roll; I *may* not be dressed and de-fuzzed yet though, so that'll be the next mission methinks.

 

ION.......

 

69**  YAHOOOOOOOOOOOOOOOOOOOO...........................😁

 

(**That's Kg, of course - though post brekkies so more like a true 68.5-ish).

 

Happy Bear.

 

BG

[jjb1970]

I remember being told by a third engineer that a diesel generator 'was *****ed, would you like me to be more specific?', yeah that might be helpful.......

[jjb1970]

4 hours ago, iL Dottore said:

I’m glad that you added that qualifier JJB. Although it is true that my knowledge of SE Asian food is not as extensive as I’d like it to be.

 

I wonder what Shi En would makes of PB’s culinary world (standards, efforts, menus etc.).

I wouldn’t worry too much about being “on the list”. The list being, I am reliably assured, scrawled in green crayon on lined paper.

 

 

Based on experience, I suspect it might be best not to ask for her opinion on curly fries...... She was singularly unimpressed by Belgian fries though in fairness I think they've gone downhill since they knocked double frying on the head. I did try and persuade her to try fillet americain as a quintessentially Belgian dish she can't get in Singapore but the concept of raw beef is an anathema to most Asian people I know, she views it in a similar way to how I view jellied eels.

[jamie92208]

6 hours ago, Coombe Barton said:

About other languages:

 

In 1983 I was skiing in Livigno and this tree reached out and grabbed me. My wrist hurt.

 

I got shunted off to the local clinic in the village which had x-ray facilities. The doc had about as much English as I had Italian, i.e. very little. Summary of conversation (Doc in very heavily accented Italian:

 

Doc: “Is beautiful break.”

 

Me: “Oh sh1t!”

 

Doc: “Sh1t?”

 

Me: “Si, sh1t.”

 

Doc: “Che?”

 

Me: “En Français?”

 

Doc: “Si.”

 

Me: “Merde.”

 

And then he started practicing. All I heard was “Sh1t …sh1t … sh1t …”

Last weekend I taught our French Houseguest the name 'flying rats' for pigeons.   He adopted the phrase forthwith as a pair were trying to build a next near their bedroom window.

5 hours ago, jjb1970 said:

I remember being told by a third engineer that a diesel generator 'was *****ed, would you like me to be more specific?', yeah that might be helpful.......

When Beth and I were driving across part of the US in 2019 we stopped in Truckee to have a coffee.  the waitress asked Beth if she wanted a refill.  Beth replied, yes I'm kn***red.   She asked what the word meant so it was explained and she said that she loved it as a word and wandered back to the kitchen repeating it loudly.   We had a similar experience over here when we taught a waitress the word 'pogged'   she taught us a patois word that means the same 'repu'.

 

Jamie

Edited April 28 by jamie92208

[PhilJ W]

2 hours ago, iL Dottore said:

Not necessarily, if a certain adverse event is seen in a large percentage of a patient population it doesn’t mean that you will experience that adverse event, just that you have a high probability of experiencing that AE.

It is a sad commentary on the state of many health services across the world that sometimes the only way to access state of the art care is to sign up to a clinical trial.

Nope, the physicians don’t get paid, the hospitals/clinics/institutions where the study is placed get paid per patient - but this is to pay for the blood work/scans/assessments/specialised pharmacy, nursing and study staff needed by a clinical trial (some institutions are notorious for charging eye gouging mark-ups on the otherwise routine tests required by a clinical trial).

The average per-patient cost in an oncology trial (which excludes things like data management or production of study drug) is about £50,000 (and can go much higher).

No clinical trial withholds essential treatment from a patient (see my earlier comment). To do so would be unethical, immoral and counterproductive (not to mention that the regulatory agencies would descend like a ton of bricks on any clever clogs trying to do so). This might have happened in the 50s and 60s, but not today.

EVERY clinical study - both observational and interventional - has to be approved by the local IRB (institutional review board)/ethics committee before being allowed to proceed. Having had to - in person - justify to a German IRB why it was necessary to perform more CT scans than local standard of care, I can tell you they are NO pushover (definitely one of the toughest meetings I’ve ever been in. Even tougher than getting an extra $20 million out of senior management). 

As for the second highlighted point - just because to a layman they seem similar, doesn’t mean they are. Different patient populations, different regimens, different drug mode-of-actions - all relevant differences (and given the cost of a clinical trial no-one does one “just for the hell of it”). As for results being published: that doesn’t mean everything is “done and dusted”. Every single drug (or surgical intervention or other patient intervention) gets continuously studied and monitored during its effective lifespan - frequently leading to new therapeutic interventions and ALWAYS to new safety data.

 

Not a clinical trial as such but about twenty five years ago I had a rather nasty urine infection. I was put on a different antibiotic each week for four weeks. Some had a negligible effect on the infection if any. After the Fourth one I told my GP that there was an improvement after the third one so he put me back on that one and the infection cleared up within a week. The cause of the infection was one of the antibiotic resistant pathogens, I don't remember now what the name of the antibiotic was. 

About six weeks ago I had another urine infection and I was passing blood and one testes was swollen to the size of a grapefruit. I immediately called 111 as it was out of surgery hours and I had an emergency consultation with a doctor who prescribed an antibiotic (nitrofurantoin) that cleared the infection straight away. I was sent for a sound scan that revealed that I had an enlarged prostate (the PSA test did not show any cancer) so I was sent to the urology department for an endoscopy which revealed the swollen prostate. The urologist was very forthcoming about what was the cause, though I didn't take it all in but apparently its some changes in my testosterone. The Urologist has put me on a course of a drug called Dutasteride for one year. 

[Tony_S]

4 hours ago, iL Dottore said:

Not necessarily, if a certain adverse event is seen in a large percentage of a patient population it doesn’t mean that you will experience that adverse event, just that you have a high probability of experiencing that AE.

 

In one oncology study I worked on significant hypotension was a common AE seen immediately after treatment and although most patients experienced hypotension, a number did not.

Depends upon the study design and the disease being treated. In life threatening disease, studies are designed so that patients get either <standard of care + new drug> or <standard of care + placebo>.

Unfortunately, in some countries and/or some diseases <standard of care> means no treatment at all beyond managed decline.

 

It is a sad commentary on the state of many health services across the world that sometimes the only way to access state of the art care is to sign up to a clinical trial.

Nope, the physicians don’t get paid, the hospitals/clinics/institutions where the study is placed get paid per patient - but this is to pay for the blood work/scans/assessments/specialised pharmacy, nursing and study staff needed by a clinical trial (some institutions are notorious for charging eye gouging mark-ups on the otherwise routine tests required by a clinical trial).

 

The average per-patient cost in an oncology trial (which excludes things like data management or production of study drug) is about £50,000 (and can go much higher).

No clinical trial withholds essential treatment from a patient (see my earlier comment). To do so would be unethical, immoral and counterproductive (not to mention that the regulatory agencies would descend like a ton of bricks on any clever clogs trying to do so). This might have happened in the 50s and 60s, but not today.

 

EVERY clinical study - both observational and interventional - has to be approved by the local IRB (institutional review board)/ethics committee before being allowed to proceed. Having had to - in person - justify to a German IRB why it was necessary to perform more CT scans than local standard of care, I can tell you they are NO pushover (definitely one of the toughest meetings I’ve ever been in. Even tougher than getting an extra $20 million out of senior management). 
 

As for the second highlighted point - just because to a layman they seem similar, doesn’t mean they are. Different patient populations, different regimens, different drug mode-of-actions - all relevant differences (and given the cost of a clinical trial no-one does one “just for the hell of it”). As for results being published: that doesn’t mean everything is “done and dusted”. Every single drug (or surgical intervention or other patient intervention) gets continuously studied and monitored during its effective lifespan - frequently leading to new therapeutic interventions and ALWAYS to new safety data.

 

So, basically my mother and I were telling lies. It wasn’t the 50s or 60s. I think the consultant was bullying an older woman and backed down when she said someone had read the information about the trial. I think he deserved to have an interview with an ethics committee. The whole treatment environment changed when she moved  to Worcestershire. 
I have signed up for loads of research projects and I have been fully informed before consent with no pressure. My mother’s situation was utterly different. 

Edited April 28 by Tony_S